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A Multiscale Model for Virus Capsid Dynamics
Joint Authors
Chen, Changjun
Wei, Guo Wei
Saxena, Rishu
Source
International Journal of Biomedical Imaging
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Viruses are infectious agents that can cause epidemics and pandemics.
The understanding of virus formation, evolution, stability, and interaction with host cells is of great importance to the scientific community and public health.
Typically, a virus complex in association with its aquatic environment poses a fabulous challenge to theoretical description and prediction.
In this work, we propose a differential geometry-based multiscale paradigm to model complex biomolecule systems.
In our approach, the differential geometry theory of surfaces and geometric measure theory are employed as a natural means to couple the macroscopic continuum domain of the fluid mechanical description of the aquatic environment from the microscopic discrete domain of the atomistic description of the biomolecule.
A multiscale action functional is constructed as a unified framework to derive the governing equations for the dynamics of different scales.
We show that the classical Navier-Stokes equation for the fluid dynamics and Newton's equation for the molecular dynamics can be derived from the least action principle.
These equations are coupled through the continuum-discrete interface whose dynamics is governed by potential driven geometric flows.
American Psychological Association (APA)
Chen, Changjun& Saxena, Rishu& Wei, Guo Wei. 2010. A Multiscale Model for Virus Capsid Dynamics. International Journal of Biomedical Imaging،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-462292
Modern Language Association (MLA)
Chen, Changjun…[et al.]. A Multiscale Model for Virus Capsid Dynamics. International Journal of Biomedical Imaging No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-462292
American Medical Association (AMA)
Chen, Changjun& Saxena, Rishu& Wei, Guo Wei. A Multiscale Model for Virus Capsid Dynamics. International Journal of Biomedical Imaging. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-462292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462292