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Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation : Effect of Ghrelin
Joint Authors
Slomiany, Amalia
SLomiany, Bronislaw L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Gastric mucosal inflammatory response to H.
pylori and its key virulence factor, lipopolysaccharide (LPS), are characterized by a massive rise in apoptosis and the disturbances in NO signaling pathways.
Here, we report that H.
pylori LPS-induced enhancement in the mucosal inducible nitric oxide synthase (iNOS) was associated with the suppression in Akt kinase activity and the impairment in constitutive nitric oxide synthase (cNOS) phosphorylation.
Further, we demonstrate that the LPS effect on Akt inactivation, manifested in the kinase protein S-nitrosylation and a decrease in its phosphorylation at Ser473, was susceptible to suppression by iNOS inhibition.
Moreover, the countering effect of hormone, ghrelin, on the LPS-induced changes in Akt activity was reflected in the loss in Akt S-nitrosylation and the increase in its phosphorylation at Ser473, as well as cNOS activation through phosphorylation.
Our findings demonstrate that up-regulation in iNOS with H.
pylori infection leads to Akt inactivation through S-nitrosylation that exerts the detrimental effect on the processes of cNOS activation through phosphorylation.
We also report that ghrelin protection against H.
pylori-induced disturbances is manifested in a marked increase in Akt activity and evoked by a decrease in the kinase S-nitrosylation and the increase in its phosphorylation at Ser473.
American Psychological Association (APA)
SLomiany, Bronislaw L.& Slomiany, Amalia. 2010. Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation : Effect of Ghrelin. ISRN Gastroenterology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462304
Modern Language Association (MLA)
SLomiany, Bronislaw L.& Slomiany, Amalia. Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation : Effect of Ghrelin. ISRN Gastroenterology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-462304
American Medical Association (AMA)
SLomiany, Bronislaw L.& Slomiany, Amalia. Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation : Effect of Ghrelin. ISRN Gastroenterology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462304