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Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice
Joint Authors
Singh, Madhulika
Shukla, Yogeshwer
Srivastava, Smita
Prasad, Sahdeo
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Glyphosate (N-(phosphonomethyl) glycine, C3H8NO5P), a herbicide, used to control unwanted annual and perennial plants all over the world.
Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings.
Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and micronuclei (MN) in bone marrow cells of Swiss albino mice.
A single dose of glyphosate was given intraperitoneally (i.p) to the animals at a concentration of 25 and 50 mg/kg b.wt.
Animals of positive control group were injected i.p.
benzo(a)pyrene (100 mg/kg b.wt., once only), whereas, animals of control (vehicle) group were injected i.p.
dimethyl sulfoxide (0.2 mL).
Animals from all the groups were sacrificed at sampling times of 24, 48, and 72 hours and their bone marrow was analyzed for cytogenetic and chromosomal damage.
Glyphosate treatment significantly increases CAs and MN induction at both treatments and time compared with the vehicle control (P<.05).
The cytotoxic effects of glyphosate were also evident, as observed by significant decrease in mitotic index (MI).
The present results indicate that glyphosate is clastogenic and cytotoxic to mouse bone marrow.
American Psychological Association (APA)
Prasad, Sahdeo& Srivastava, Smita& Singh, Madhulika& Shukla, Yogeshwer. 2009. Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice. Journal of Toxicology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-462322
Modern Language Association (MLA)
Prasad, Sahdeo…[et al.]. Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice. Journal of Toxicology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-462322
American Medical Association (AMA)
Prasad, Sahdeo& Srivastava, Smita& Singh, Madhulika& Shukla, Yogeshwer. Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice. Journal of Toxicology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-462322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462322