Chronic Neuroinflammation in Alzheimer’s Disease : New Perspectives on Animal Models and Promising Candidate Drugs
Joint Authors
Campbell, Iain L.
Rangel, Alejandra
Millington, Christopher
Sonego, Sandra
Aldrich-Wright, Janice R.
Gyengesi, Erika
Münch, Gerald
Karunaweera, Niloo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic neuroinflammation is now considered one of the major factors in the pathogenesis of Alzheimer’s disease (AD).
However, the most widely used transgenic AD models (overexpressing mutated forms of amyloid precursor protein, presenilin, and/or tau) do not demonstrate the degree of inflammation, neurodegeneration (particularly of the cholinergic system), and cognitive decline that is comparable with the human disease.
Hence a more suitable animal model is needed to more closely mimic the resulting cognitive decline and memory loss in humans in order to investigate the effects of neuroinflammation on neurodegeneration.
One of these models is the glial fibrillary acidic protein-interleukin 6 (GFAP-IL6) mouse, in which chronic neuroinflammation triggered constitutive expression of the cytokine interleukin-6 (IL-6) in astrocytes.
These transgenic mice show substantial and progressive neurodegeneration as well as a decline in motor skills and cognitive function, starting from 6 months of age.
This animal model could serve as an excellent tool for drug discovery and validation in vivo.
In this review, we have also selected three potential anti-inflammatory drugs, curcumin, apigenin, and tenilsetam, as candidate drugs, which could be tested in this model.
American Psychological Association (APA)
Millington, Christopher& Sonego, Sandra& Karunaweera, Niloo& Rangel, Alejandra& Aldrich-Wright, Janice R.& Campbell, Iain L.…[et al.]. 2014. Chronic Neuroinflammation in Alzheimer’s Disease : New Perspectives on Animal Models and Promising Candidate Drugs. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-462335
Modern Language Association (MLA)
Millington, Christopher…[et al.]. Chronic Neuroinflammation in Alzheimer’s Disease : New Perspectives on Animal Models and Promising Candidate Drugs. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-462335
American Medical Association (AMA)
Millington, Christopher& Sonego, Sandra& Karunaweera, Niloo& Rangel, Alejandra& Aldrich-Wright, Janice R.& Campbell, Iain L.…[et al.]. Chronic Neuroinflammation in Alzheimer’s Disease : New Perspectives on Animal Models and Promising Candidate Drugs. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-462335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462335