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Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB
Joint Authors
Wu, Xiaoting
Liu, Jie
Chen, Yi
Nice, Edouard Collins
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study explores the therapeutic effects of Xiangshao granules in a mouse depression model and examines the potential molecular mechanisms involved.
After 21 consecutive days of chronic stress challenge, all mice were divided into three groups: control group, depression group, and Xiangshao granule treatment group.
On the 22nd day, rats in the Xiangshao granule treatment group received Xiangshao granules via gastrogavage for 3 consecutive weeks.
Depression group mice showed a significant reduction of crossings (P<0.01) but not rearings (P<0.05).
Serum CRH, CORT, and ACTH levels were significantly increased in depression mice compared with control (P<0.05) and the expression levels of hippocampal BDNF and TrkB were reduced in the model group (P<0.05).
However, Xiangshao granule treatment remarkably rescued the decrease in the body weight (P<0.05), increased crossings in the open field test (P<0.05), upregulated the expression of hippocampal BDNF and TrkB expression, and reduced the serum CRH, CORT, and ACTH concentrations compared with the depression group (P<0.05).
Collectively, these results demonstrated that Xiangshao granule could effectively induce antidepressive effects in the depression mouse model by ameliorating the expression of hippocampal BDNF and TrkB.
American Psychological Association (APA)
Chen, Yi& Liu, Jie& Wu, Xiaoting& Nice, Edouard Collins. 2013. Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-462353
Modern Language Association (MLA)
Chen, Yi…[et al.]. Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-462353
American Medical Association (AMA)
Chen, Yi& Liu, Jie& Wu, Xiaoting& Nice, Edouard Collins. Xiangshao Granule Exerts Antidepressive Effects in a Depression Mouse Model by Ameliorating Deficits in Hippocampal BDNF and TrkB. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-462353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462353