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Characterization of Zebrafish Pax1b and Pax9 in Fin Bud Development
Joint Authors
Gao, Rui
Zhao, Liang
Wang, Yiquan
Pan, Zhuma
Guo, Fengjin
Du, Xiaogang
Song, Lin
Ma, Linqiang
Chen, Xuemei
Lei, Han
Gui, Haibo
He, Junling
Huang, Huizhe
Liu, Xin
Wang, Hua
Yuan, Taixian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Both Pax1 and Pax9 belong to the important paired box gene family (PAX), which mainly participates in animal development and sclerotome differentiation.
To date, the precise molecular mechanism and related signaling pathway of Pax1 remain unclear.
In our study, microinjection of morpholino- (MO-) modified antisense oligonucleotides against pax1b induced pectoral fin bud defects.
Furthermore, we demonstrate that the phenotypes caused by the knockdown of Pax1b in zebrafish could not be phenocopied by pax9 MO and could not be rescued by either Pax1a or Pax9 overexpression.
We further find that Pax1b affects the expression of col2a1, Uncx4.1, Noggin3, and aggrecan, confirming the role of Pax1b in chondrocyte differentiation and bone maturation.
Moreover, we identify an interaction between PAX1 and FOXO1 and find that the interaction was enhanced under hypoxia stress.
Together, this evidence for cell death caused by pax1b knockdown provides new insight into the role of the Pax protein family in cell fate determination and tissue specification.
American Psychological Association (APA)
Chen, Xuemei& Huang, Huizhe& Wang, Hua& Guo, Fengjin& Du, Xiaogang& Ma, Linqiang…[et al.]. 2014. Characterization of Zebrafish Pax1b and Pax9 in Fin Bud Development. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462365
Modern Language Association (MLA)
Chen, Xuemei…[et al.]. Characterization of Zebrafish Pax1b and Pax9 in Fin Bud Development. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-462365
American Medical Association (AMA)
Chen, Xuemei& Huang, Huizhe& Wang, Hua& Guo, Fengjin& Du, Xiaogang& Ma, Linqiang…[et al.]. Characterization of Zebrafish Pax1b and Pax9 in Fin Bud Development. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462365