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Acquired Myelodysplasia or Myelodysplastic Syndrome : Clearing the Fog
Joint Authors
Natelson, Ethan A.
Pyatt, David
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Myelodysplastic syndromes (MDS) are clonal myeloid disorders characterized by progressive peripheral blood cytopenias associated with ineffective myelopoiesis.
They are typically considered neoplasms because of frequent genetic aberrations and patient-limited survival with progression to acute myeloid leukemia (AML) or death related to the consequences of bone marrow failure including infection, hemorrhage, and iron overload.
A progression to AML has always been recognized among the myeloproliferative disorders (MPD) but occurs only rarely among those with essential thrombocythemia (ET).
Yet, the World Health Organization (WHO) has chosen to apply the designation myeloproliferative neoplasms (MPN), for all MPD but has not similarly recommended that all MDS become the myelodysplastic neoplasms (MDN).
This apparent dichotomy may reflect the extremely diverse nature of MDS.
Moreover, the term MDS is occasionally inappropriately applied to hematologic disorders associated with acquired morphologic myelodysplastic features which may rather represent potentially reversible hematological responses to immune-mediated factors, nutritional deficiency states, and disordered myelopoietic responses to various pharmaceutical, herbal, or other potentially myelotoxic compounds.
We emphasize the clinical settings, and the histopathologic features, of such AMD that should trigger a search for a reversible underlying condition that may be nonneoplastic and not MDS.
American Psychological Association (APA)
Natelson, Ethan A.& Pyatt, David. 2013. Acquired Myelodysplasia or Myelodysplastic Syndrome : Clearing the Fog. Advances in Hematology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-462396
Modern Language Association (MLA)
Natelson, Ethan A.& Pyatt, David. Acquired Myelodysplasia or Myelodysplastic Syndrome : Clearing the Fog. Advances in Hematology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-462396
American Medical Association (AMA)
Natelson, Ethan A.& Pyatt, David. Acquired Myelodysplasia or Myelodysplastic Syndrome : Clearing the Fog. Advances in Hematology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-462396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462396