Synthesis and biological activity studies of some novel metal complexes derivate from 2-(2-imino-1- methylimidazolidin-4-ylidene)‎ hydrazinecarbothioamide

Abstract EN

2- (2-imino-1-methylimidazolidin-4-ylidene) hydrazinecarbothioamide react with chlorides of Cr(III), Co(II), Ni(II) and Cu(II) to yield metal ion complexes of definite composition.

These compounds were characterized by elemental analyses, magnetic susceptibility measurements, UV-visible, 1H-NMR and FT-IR spectral investigations.

The ligand was studied by using of theoretical method (Simi empirical AMI module in the CS ChemOffice molecular modeling package) by calculation of heat of formation, bond length, bond angle and dihedral angle.

The stability for the prepared complexes was studied theoretically by the Density Function Theory (DFT).

The free ligand and their metal complexes have been tested in vitro against a number of micro-organisms (Staphylococcus aureus, E.

coli, Proteus vulgaris, Pseudomonas, and Klebsiella pneumoniae) , in order to assess their antimicrobial activities.

The ligand and its complexes showed considerable activity against all bacteria.