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Combined Effect of Subchondral Drilling and Hyaluronic Acid withwithout Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits
Joint Authors
Laupattarakasem, Wiroon
Sukon, Peerapol
Laupattarakasem, Pisamai
Suwannaloet, Wanwisa
Ong-Chai, Siriwan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits.
A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee.
A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3).
Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3).
The animals were then sacrificed for evaluation.
The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control.
In addition, adding oral diacerein to HA injection enhanced healing potential of HA.
American Psychological Association (APA)
Suwannaloet, Wanwisa& Laupattarakasem, Wiroon& Sukon, Peerapol& Ong-Chai, Siriwan& Laupattarakasem, Pisamai. 2012. Combined Effect of Subchondral Drilling and Hyaluronic Acid withwithout Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462486
Modern Language Association (MLA)
Suwannaloet, Wanwisa…[et al.]. Combined Effect of Subchondral Drilling and Hyaluronic Acid withwithout Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-462486
American Medical Association (AMA)
Suwannaloet, Wanwisa& Laupattarakasem, Wiroon& Sukon, Peerapol& Ong-Chai, Siriwan& Laupattarakasem, Pisamai. Combined Effect of Subchondral Drilling and Hyaluronic Acid withwithout Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462486