![](/images/graphics-bg.png)
Stem Cells for Cardiac Repair : Status, Mechanisms, and New Strategies
Joint Authors
Bo, Zhang
Mingliang, Ren
Zhengguo, Wang
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure.
Stem cells have the potential of self-renewal and differentiation.
It is expected to replace and repair damaged myocardium.
But many clinical trials have shown that the stem cell therapy of heart failure is modest or not effective.
The possible causes for the limited effects of stem cell in curing heart failure are the stem cells which have been transplanted into the ischemic heart muscle may suffer low survival rate, affected by inflammatory molecules, proapoptotic factor, and lack of nutrients and oxygen, and then the stem cells which home and have been completely transplanted to the site of myocardial infarction become very small.
Therefore, through preconditioning of stem cells and appropriate choice of genes for mesenchymal stem cell modification to improve the survival rate of stem cells, ability in homing and promoting angiogenesis may become the newly effective strategies for the application of stem cells therapy in heart failure.
American Psychological Association (APA)
Mingliang, Ren& Bo, Zhang& Zhengguo, Wang. 2011. Stem Cells for Cardiac Repair : Status, Mechanisms, and New Strategies. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462506
Modern Language Association (MLA)
Mingliang, Ren…[et al.]. Stem Cells for Cardiac Repair : Status, Mechanisms, and New Strategies. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-462506
American Medical Association (AMA)
Mingliang, Ren& Bo, Zhang& Zhengguo, Wang. Stem Cells for Cardiac Repair : Status, Mechanisms, and New Strategies. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462506