Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice
Joint Authors
Lee, Gihyun
Bae, Hyunsu
Lee, Hyojung
Kim, Hyunseong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cisplatin is an effective chemotherapeutic agent that is used for the treatment of a variety of cancers; however, its nephrotoxicity limits the use of this drug.
In the present study, we examined whether paeonol, a major compound of Moutan Cortex, has protective effects on cisplatin-induced acute renal failure in mice.
To accomplish this, Balb/c mice (6 to 8 wk of age, weighing 20 to 25 g) were administered, Moutan Cortex (300 mg/kg) or paeonol (20 mg/kg) once a day.
At day 4, mice received cisplatin (30, 20, or 10 mg/kg) intraperitoneally.
The paeonol-treated group showed marked attenuation of serum creatine and blood urea nitrogen levels as well as reduced levels of proinflammatory cytokines and nitric oxide when compared to the control group.
In addition, the paeonol-treated group showed prolonged survival and marked attenuation of renal tissue injury.
Taken together, these results demonstrated that paeonol can prevent the renal toxic effects of cisplatin.
American Psychological Association (APA)
Lee, Hyojung& Lee, Gihyun& Kim, Hyunseong& Bae, Hyunsu. 2013. Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462513
Modern Language Association (MLA)
Lee, Hyojung…[et al.]. Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462513
American Medical Association (AMA)
Lee, Hyojung& Lee, Gihyun& Kim, Hyunseong& Bae, Hyunsu. Paeonol, a Major Compound of Moutan Cortex, Attenuates Cisplatin-Induced Nephrotoxicity in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462513