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Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice
Joint Authors
Romero, Luz
Zamanillo, Daniel
Brenchat, Alex
Vela, José Miguel
Rocasalbas, Maria
Hamon, Michel
Source
Advances in Pharmacological Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
No study has ever examined the effect of 5-HT7 receptor agonists on nociception by using 5-HT7 receptor knockout mice.
Basal sensitivity to noxious heat stimuli and formalin-induced nociception in both phase I and II of the formalin test did not differ in 5-HT7 receptor knockout mice and paired wild-type controls.
Similarly, there was no significant difference in basal body temperature between both genotypes.
Subcutaneous administration of 5-HT7 receptor agonists AS-19 (10 mg/kg), E-57431 (10 mg/kg), and E-55888 (20 mg/kg) significantly reduced formalin-induced licking/biting behavior during the phase II of the test in wild-type but not in 5-HT7 receptor knockout mice.
At these active analgesic doses, none of the three 5-HT7 receptor agonists modified the basal body temperature neither in wild-type nor in 5-HT7 receptor knockout mice.
However, a significant decrease in body temperature was observed at a higher dose (20 mg/kg) of AS-19 and E-57431 in both genotypes.
Our data strongly suggest that the 5-HT7 receptor agonists AS-19, E-57431, and E-55888 produce antinociception in the formalin test by activating 5-HT7 receptors.
These results also strengthen the idea that the 5-HT7 receptor plays a role in thermoregulation, but by acting in concert with other receptors.
American Psychological Association (APA)
Brenchat, Alex& Rocasalbas, Maria& Zamanillo, Daniel& Hamon, Michel& Vela, José Miguel& Romero, Luz. 2012. Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice. Advances in Pharmacological Sciences،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462518
Modern Language Association (MLA)
Brenchat, Alex…[et al.]. Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice. Advances in Pharmacological Sciences No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-462518
American Medical Association (AMA)
Brenchat, Alex& Rocasalbas, Maria& Zamanillo, Daniel& Hamon, Michel& Vela, José Miguel& Romero, Luz. Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice. Advances in Pharmacological Sciences. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462518