High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma
Joint Authors
Chen, Aishan
Yin, Hongzhuan
Sun, Wei
Liu, Baolin
Shang, Bin
Cao, Xiankui
Su, Qi
Source
International Journal of Genomics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Polo-like kinase 1 (PLK1), one of serine/threonine-protein kinase, has been demonstrated to play pivotal roles in malignant transformation.
Here we illustrated the clinicopathological significance of PLK1 expression in hepatocellular carcinoma (HCC) in more detail.
Immunohistochemistry was performed to detect the expression of PLK1 in 67 HCC patients as well as corresponding noncancerous liver tissues.
In addition, the correlation of PLK1 expression with clinicopathological factors or prognosis of HCC was analyzed.
Results showed that the expression of PLK1 was increased significantly in HCC tissues than that of corresponding normal liver tissues.
The correlation between PLK1 and HCC cell differentiation or capsule invasion was also revealed.
We found that PLK1 inhibition promoted cell arrest in G2/M phase of cell cycle and cell apoptosis.
Our results also indicated that the potential mechanisms of PLK1 inhibition regulating cell growth involved enhancing expression of caspase3, caspase8, and Bax and decreasing expression of Bcl-2.
Furthermore, we also found that PLK1 downregulation inducing inhibition of cell growth was associated with enhancing expression of p53.
Thus, we presume that the status of PLK1 expression might be an independent prognostic factor for HCC and targeting PLK1 might be a useful strategy for diagnosis and treatment of human HCC.
American Psychological Association (APA)
Sun, Wei& Su, Qi& Cao, Xiankui& Shang, Bin& Chen, Aishan& Yin, Hongzhuan…[et al.]. 2014. High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma. International Journal of Genomics،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462528
Modern Language Association (MLA)
Sun, Wei…[et al.]. High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma. International Journal of Genomics No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-462528
American Medical Association (AMA)
Sun, Wei& Su, Qi& Cao, Xiankui& Shang, Bin& Chen, Aishan& Yin, Hongzhuan…[et al.]. High Expression of Polo-Like Kinase 1 Is Associated with Early Development of Hepatocellular Carcinoma. International Journal of Genomics. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462528