Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition
Joint Authors
Campbell, Michael S.
Bagley, Heidi N.
Lane, Robert H.
Joss-Moore, Lisa A.
Wang, Yan
Yu, Xing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Intrauterine growth restriction (IUGR) predisposes to obesity and adipose dysfunction.
We previously demonstrated IUGR-induced increased visceral adipose deposition and dysregulated expression of peroxisome proliferator activated receptor-γ2 (PPARγ2) in male adolescent rats, prior to the onset of obesity.
In other studies, activation of PPARγ increases subcutaneous adiponectin expression and normalizes visceral adipose deposition.
We hypothesized that maternal supplementation with docosahexaenoic acid (DHA), a PPARγ agonist, would normalize IUGR adipose deposition in association with increased PPARγ, adiponectin, and adiponectin receptor expression in subcutaneous adipose.
To test these hypotheses, we used a well-characterized model of uteroplacental-insufficiency-(UPI-) induced IUGR in the rat with maternal DHA supplementation.
Our primary findings were that maternal DHA supplementation during rat pregnancy and lactation (1) normalizes IUGR-induced changes in adipose deposition and visceral PPARγ expression in male rats and (2) increases serum adiponectin, as well as adipose expression of adiponectin and adiponectin receptors in former IUGR rats.
Our novel findings suggest that maternal DHA supplementation may normalize adipose dysfunction and promote adiponectin-induced improvements in metabolic function in IUGR.
American Psychological Association (APA)
Bagley, Heidi N.& Wang, Yan& Campbell, Michael S.& Yu, Xing& Lane, Robert H.& Joss-Moore, Lisa A.. 2013. Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition. Journal of Obesity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462533
Modern Language Association (MLA)
Bagley, Heidi N.…[et al.]. Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition. Journal of Obesity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462533
American Medical Association (AMA)
Bagley, Heidi N.& Wang, Yan& Campbell, Michael S.& Yu, Xing& Lane, Robert H.& Joss-Moore, Lisa A.. Maternal Docosahexaenoic Acid Increases Adiponectin and Normalizes IUGR-Induced Changes in Rat Adipose Deposition. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462533