Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia
Joint Authors
Su, Hong-Lin
Lin, Yi-Wen
Huang, Chun-Ping
Lai, Zhen-Rung
Chen, Hsiang-Ni
Hsieh, Ching-Liang
Chen, Wei-Hsin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Several voltage-gated sodium channels (Navs) from nociceptive nerve fibers have been identified as important effectors in pain signaling.
The objective of this study is to investigate the electroacupuncture (EA) analgesia mechanism by changing the expression of Navs in mice dorsal root ganglia (DRG).
We injected carrageenan and complete Freund's adjuvant (CFA) into the mice plantar surface of the hind paw to induce inflammation and examined the antinociception effect of EA at the Zusanli (ST36) acupoint at 2 Hz low frequency.
Mechanical hyperalgesia was evaluated by using electronic von Frey filaments, and thermal hyperalgesia was assessed using Hargreaves' test.
Furthermore, we observed the expression and quality of Navs in DRG neurons.
Our results showed that EA reduced mechanical and thermal pain in inflammatory animal model.
The expression of Nav1.7 and Nav1.8 was increased after 4 days of carrageenan- and CFA-elicited inflammatory pain and further attenuated by 2 Hz EA stimulation.
The attenuation cannot be observed in Nav1.9 sodium channels.
We demonstrated that EA at Zusanli (ST36) acupoint at 2 Hz low-frequency stimulation attenuated inflammatory pain accompanied by decreasing the expression of Nav1.7 and 1.8, rather than Nav1.9, sodium channels in peripheral DRG neurons.
American Psychological Association (APA)
Huang, Chun-Ping& Chen, Hsiang-Ni& Su, Hong-Lin& Hsieh, Ching-Liang& Chen, Wei-Hsin& Lai, Zhen-Rung…[et al.]. 2013. Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462538
Modern Language Association (MLA)
Huang, Chun-Ping…[et al.]. Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-462538
American Medical Association (AMA)
Huang, Chun-Ping& Chen, Hsiang-Ni& Su, Hong-Lin& Hsieh, Ching-Liang& Chen, Wei-Hsin& Lai, Zhen-Rung…[et al.]. Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462538