New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics
Joint Authors
Toscani, Denise
Dalla Palma, Benedetta
Abati, Caterina
Bolzoni, Marina
Racano, Costantina
Magnani, Marina
Facchini, Andrea
Manferdini, Cristina
Spolzino, Angelica
Lisignoli, Gina
Aversa, Franco
Giuliani, Nicola
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes.
The osteogenic differentiation of hMSCs is regulated either by systemic hormones or by local growth factors able to induce specific intracellular signal pathways that modify the expression and activity of several transcription factors.
Runt-related transcription factor 2 (Runx2) and Wnt signaling-related molecules are the major factors critically involved in the osteogenic differentiation process by hMSCs, and SRY-related high-mobility-group (HMG) box transcription factor 9 (SOX9) is involved in the chondrogenic one.
hMSCs have generated a great interest in the field of regenerative medicine, particularly in bone regeneration.
In this paper, we focused our attention on the molecular mechanisms involved in osteogenic and chondrogenic differentiation of hMSC, and the potential clinical use of hMSCs in osteoarticular pediatric disease characterized by fracture nonunion and pseudarthrosis.
American Psychological Association (APA)
Giuliani, Nicola& Lisignoli, Gina& Magnani, Marina& Racano, Costantina& Bolzoni, Marina& Dalla Palma, Benedetta…[et al.]. 2013. New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics. Stem Cells International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-462560
Modern Language Association (MLA)
Giuliani, Nicola…[et al.]. New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics. Stem Cells International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-462560
American Medical Association (AMA)
Giuliani, Nicola& Lisignoli, Gina& Magnani, Marina& Racano, Costantina& Bolzoni, Marina& Dalla Palma, Benedetta…[et al.]. New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-462560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462560