Overall Memory Impairment Identification with Mathematical Modeling of the CVLT-II Learning Curve in Multiple Sclerosis
Joint Authors
Hoogs, Marietta
Stepanov, Igor I.
Benedict, Ralph H. B.
Abramson, Charles I.
Source
Multiple Sclerosis International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The CVLT-II provides standardized scores for each of the List A five learning trials, so that the clinician can compare the patient's raw trials 1–5 scores with standardized ones.
However, frequently, a patient's raw scores fluctuate making a proper interpretation difficult.
The CVLT-II does not offer any other methods for classifying a patient's learning and memory status on the background of the learning curve.
The main objective of this research is to illustrate that discriminant analysis provides an accurate assessment of the learning curve, if suitable predictor variables are selected.
Normal controls were ninety-eight healthy volunteers (78 females and 20 males).
A group of MS patients included 365 patients (266 females and 99 males) with clinically defined multiple sclerosis.
We show that the best predictor variables are coefficients B3 and B4 of our mathematical model B3 ∗ exp(−B2 ∗ (X−1))+B4 ∗ (1−exp(−B2 ∗ (X−1))) because discriminant functions, calculated separately for B3 and B4, allow nearly 100% correct classification.
These predictors allow identification of separate impairment of readiness to learn or ability to learn, or both.
American Psychological Association (APA)
Stepanov, Igor I.& Abramson, Charles I.& Hoogs, Marietta& Benedict, Ralph H. B.. 2012. Overall Memory Impairment Identification with Mathematical Modeling of the CVLT-II Learning Curve in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-462561
Modern Language Association (MLA)
Stepanov, Igor I.…[et al.]. Overall Memory Impairment Identification with Mathematical Modeling of the CVLT-II Learning Curve in Multiple Sclerosis. Multiple Sclerosis International No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-462561
American Medical Association (AMA)
Stepanov, Igor I.& Abramson, Charles I.& Hoogs, Marietta& Benedict, Ralph H. B.. Overall Memory Impairment Identification with Mathematical Modeling of the CVLT-II Learning Curve in Multiple Sclerosis. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-462561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462561