Toxicity and Neuropharmacological Effects of Elenine
Joint Authors
Alonso, S. J.
Navarro, Eduardo
Navarro, R.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived from Justicia hyssopifolia.
(Family: Acanthaceae).
Elenoside is a β-D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity.
In the present study, elenine was given to mice and rats at doses of 10, 20, and 40 mg/kg.
Acute toxicity (24 h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10 mg/kg of chlorpromazine.
Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test).
Spontaneous activity was lower in the Varimex test.
The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test.
Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.
American Psychological Association (APA)
Navarro, Eduardo& Alonso, S. J.& Navarro, R.. 2011. Toxicity and Neuropharmacological Effects of Elenine. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462563
Modern Language Association (MLA)
Navarro, Eduardo…[et al.]. Toxicity and Neuropharmacological Effects of Elenine. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462563
American Medical Association (AMA)
Navarro, Eduardo& Alonso, S. J.& Navarro, R.. Toxicity and Neuropharmacological Effects of Elenine. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462563