Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus
Joint Authors
Carroll, Rona S.
Jääskeläinen, Juha E.
Black, Peter M.
Dello Iacono, Donna
Leinonen, Ville
Menon, Lata G.
Grevet, Jeremy
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is still challenging.
Alzheimer's disease (AD), along with vascular dementia, the most important differential diagnosis for iNPH, has several potential cerebrospinal fluid (CSF) biomarkers which might help in the selection of patients for shunt treatment.
The aim of this study was to compare a battery of CSF biomarkers including well-known AD-related proteins with CSF from patients with suspected iNPH collected from the external lumbar drainage test (ELD).
A total of 35 patients with suspected iNPH patients were evaluated with ELD.
CSF was collected in the beginning of the test, and the concentrations of total tau, ptau181, Aβ42, NFL, TNF-α, TGFβ1, and VEGF were analysed by ELISA.
Twenty-six patients had a positive ELD result—that is, their gait symptoms improved; 9 patients had negative ELD.
The levels of all analyzed CSF biomarkers were similar between the groups and none of them predicted the ELD result in these patients.
Contrary to expectations lumbar CSF TNF-α concentration was low in iNPH patients.
American Psychological Association (APA)
Leinonen, Ville& Menon, Lata G.& Carroll, Rona S.& Dello Iacono, Donna& Grevet, Jeremy& Jääskeläinen, Juha E.…[et al.]. 2011. Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-462564
Modern Language Association (MLA)
Leinonen, Ville…[et al.]. Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-462564
American Medical Association (AMA)
Leinonen, Ville& Menon, Lata G.& Carroll, Rona S.& Dello Iacono, Donna& Grevet, Jeremy& Jääskeläinen, Juha E.…[et al.]. Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-462564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462564