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Infliximab Reverses Suppression of Cholesterol Efflux Proteins by TNF-α : A Possible Mechanism for Modulation of Atherogenesis
Joint Authors
Belilos, Elise
Seshadri, Sangeetha
Carsons, Steven E.
Voloshyna, Iryna
Anwar, Kamran
Reiss, Allison B.
Littlefield, Michael J.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumor necrosis factor- (TNF-) α is a proinflammatory proatherogenic cytokine.
Infliximab, an anti-TNF-α monoclonal antibody, is effective in treating rheumatoid arthritis.
However, its impact on cardiovascular burden and lipid transport is unclear.
The present study investigates the effect of TNF-α and infliximab on reverse cholesterol transport (RCT) proteins.
Uptake of modified lipoproteins by macrophages in the vasculature leads to atherogenic foam cell formation.
RCT is mediated by proteins including ATP binding cassette transporters A1 (ABCA1), G1 (ABCG1), liver X receptor- (LXR-) α, and 27-hydroxylase.
RCT counteracts lipid overload by ridding cells of excess cholesterol.
THP-1 human monocytes were incubated with either TNF-α alone or TNF-α with infliximab.
Expression of proteins involved in cholesterol efflux was analyzed.
TNF-α significantly reduced both ABCA1 and LXR-α mRNA (to 68.5±1.59%, P<0.05, and 41.2±0.25%, P<0.01, versus control set as 100%, resp.).
Infliximab nullified the TNF-α effect.
Results were confirmed by Western blot.
Infliximab abolished the increase in foam cells induced by TNF-α.
TNF-α treatment significantly reduces ABCA1 and LXR-α expression in monocytes, thus bringing about a proatherogenic state.
The anti-TNF drug infliximab, commonly used in rheumatology, restored RCT proteins.
This is the first report of an atheroprotective effect of infliximab on RCT in monocytes.
American Psychological Association (APA)
Voloshyna, Iryna& Seshadri, Sangeetha& Anwar, Kamran& Littlefield, Michael J.& Belilos, Elise& Carsons, Steven E.…[et al.]. 2014. Infliximab Reverses Suppression of Cholesterol Efflux Proteins by TNF-α : A Possible Mechanism for Modulation of Atherogenesis. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-462579
Modern Language Association (MLA)
Voloshyna, Iryna…[et al.]. Infliximab Reverses Suppression of Cholesterol Efflux Proteins by TNF-α : A Possible Mechanism for Modulation of Atherogenesis. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-462579
American Medical Association (AMA)
Voloshyna, Iryna& Seshadri, Sangeetha& Anwar, Kamran& Littlefield, Michael J.& Belilos, Elise& Carsons, Steven E.…[et al.]. Infliximab Reverses Suppression of Cholesterol Efflux Proteins by TNF-α : A Possible Mechanism for Modulation of Atherogenesis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-462579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462579