Physiopathogenetic Interrelationship between Nocturnal Frontal Lobe Epilepsy and NREM Arousal Parasomnias
Joint Authors
Szűcs, Anna
Kelemen, Anna
Halász, Péter
Source
Epilepsy Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To build up a coherent shared pathophysiology of NFLE and AP and discuss the underlying functional network.
Methods.
Reviewing relevant published data we point out common features in semiology of events, relations to macro- and microstructural dynamism of NREM sleep, to cholinergic arousal mechanism and genetic aspects.
Results.
We propose that pathological arousals accompanied by confused behavior with autonomic signs and/or hypermotor automatisms are expressions of the frontal cholinergic arousal function of different degree, during the condition of depressed cognition by frontodorsal functional loss in NREM sleep.
This may happen either if the frontal cortical Ach receptors are mutated in ADNFLE (and probably also in genetically not proved nonlesional cases as well), or without epileptic disorder, in AP, assuming gain in receptor functions in both conditions.
This hypothesis incorporates the previous “liberation theory” of Tassinari and the “state dissociation hypothesis” of Bassetti and Terzaghi).
We propose that NFLE and IGE represent epileptic disorders of the two antagonistic twin systems in the frontal lobe.
NFLE is the epileptic facilitation of the ergotropic frontal arousal system whereas absence epilepsy is the epileptic facilitation of burst-firing working mode of the spindle and delta producing frontal thalamocortical throphotropic sleep system.
Significance.
The proposed physiopathogenesis conceptualize epilepsies in physiologically meaningful networks.
American Psychological Association (APA)
Halász, Péter& Kelemen, Anna& Szűcs, Anna. 2012. Physiopathogenetic Interrelationship between Nocturnal Frontal Lobe Epilepsy and NREM Arousal Parasomnias. Epilepsy Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462582
Modern Language Association (MLA)
Halász, Péter…[et al.]. Physiopathogenetic Interrelationship between Nocturnal Frontal Lobe Epilepsy and NREM Arousal Parasomnias. Epilepsy Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-462582
American Medical Association (AMA)
Halász, Péter& Kelemen, Anna& Szűcs, Anna. Physiopathogenetic Interrelationship between Nocturnal Frontal Lobe Epilepsy and NREM Arousal Parasomnias. Epilepsy Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462582