The β-SiC Nanowires (~100 nm) Induce Apoptosis via Oxidative Stress in Mouse Osteoblastic Cell Line MC3T3-E1
Joint Authors
Jin, Meishan
Wen, Guangwu
Xie, Qi
Huang, Xiaoxiao
Xie, Weili
Zhang, Xiaodong
Shao, Zhengkai
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Silicon carbide (SiC), a compound of silicon and carbon, with chemical formula SiC, the beta modification (β-SiC), with a zinc blende crystal structure (similar to diamond), is formed at temperature below 1700∘C.
β-SiC will be the most suitable ceramic material for the future hard tissue replacement, such as bone and tooth.
The in vitro cytotoxicity of β-SiC nanowires was investigated for the first time.
Our results indicated that 100 nm long SiC nanowires could significantly induce the apoptosis in MC3T3-E1 cells, compared with 100 μm long SiC nanowires.
And 100 nm long SiC nanowires increased oxidative stress in MC3T3-E1 cells, as determined by the concentrations of MDA (as a marker of lipid peroxidation) and 8-OHdG (indicator of oxidative DNA damage).
Moreover, transmission electron microscopy (TEM) was performed to evaluate the morphological changes of MC3T3-E1 cells.
After treatment with 100 nm long SiC nanowires, the mitochondria were swelled and disintegrated, and the production of ATP and the total oxygen uptake were also decreased significantly.
Therefore, β-SiC nanowires may have limitations as medical material.
American Psychological Association (APA)
Xie, Weili& Xie, Qi& Jin, Meishan& Huang, Xiaoxiao& Zhang, Xiaodong& Shao, Zhengkai…[et al.]. 2014. The β-SiC Nanowires (~100 nm) Induce Apoptosis via Oxidative Stress in Mouse Osteoblastic Cell Line MC3T3-E1. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462608
Modern Language Association (MLA)
Xie, Weili…[et al.]. The β-SiC Nanowires (~100 nm) Induce Apoptosis via Oxidative Stress in Mouse Osteoblastic Cell Line MC3T3-E1. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-462608
American Medical Association (AMA)
Xie, Weili& Xie, Qi& Jin, Meishan& Huang, Xiaoxiao& Zhang, Xiaodong& Shao, Zhengkai…[et al.]. The β-SiC Nanowires (~100 nm) Induce Apoptosis via Oxidative Stress in Mouse Osteoblastic Cell Line MC3T3-E1. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-462608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462608