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ER Stress and Lipid Metabolism in Adipocytes
Joint Authors
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
The role of endoplasmic reticulum (ER) stress is a rapidly emerging field of interest in the pathogenesis of metabolic diseases.
Recent studies have shown that chronic activation of ER stress is closely linked to dysregulation of lipid metabolism in several metabolically important cells including hepatocytes, macrophages, β-cells, and adipocytes.
Adipocytes are one of the major cell types involved in the pathogenesis of the metabolic syndrome.
Recent advances in dissecting the cellular and molecular mechanisms involved in the regulation of adipogenesis and lipid metabolism indicate that activation of ER stress plays a central role in regulating adipocyte function.
In this paper, we discuss the current understanding of the potential role of ER stress in lipid metabolism in adipocytes.
In addition, we touch upon the interaction of ER stress and autophagy as well as inflammation.
Inhibition of ER stress has the potential of decreasing the pathology in adipose tissue that is seen with energy overbalance.
American Psychological Association (APA)
Zha, Beth S.& Zhou, Huiping. 2012. ER Stress and Lipid Metabolism in Adipocytes. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462611
Modern Language Association (MLA)
Zha, Beth S.& Zhou, Huiping. ER Stress and Lipid Metabolism in Adipocytes. Biochemistry Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-462611
American Medical Association (AMA)
Zha, Beth S.& Zhou, Huiping. ER Stress and Lipid Metabolism in Adipocytes. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-462611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462611