Oxidative Stress Indicators in Patients with Prostate Disorders in Enugu, South-East Nigeria
Joint Authors
Duru, Romanda
Njoku, Obioma
Maduka, Ignatius
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Depletion of cellular antioxidants can result from free radical formation due to normal endogenous reactions and the ingestion of exogenous substances and environmental factors.
The levels of reactive oxygen species-(ROS-) scavenging enzymes such as SOD and glutathione peroxidase have been shown to be significantly altered in malignant cells and in primary cancer tissues.
The aim of this study was to determine the antioxidant status of patients with prostate disorders in South-East Nigeria to ascertain the possible role of depletion of antioxidants in prostatic degeneration.
104 subjects made up of 40 PCa patients, 32 with BPH, and 32 controls participated in this study.
The levels of superoxide dismutase, glutathione peroxidase, vitamin C, and vitamin E were estimated using standard procedures.
The results show that both the BPH and PCa patients had a significant decrease (P<0.05) in GPX, SOD, vitamin C, and vitamin E levels compared to the control subjects.
However, there was also a significant decrease (P<0.05) in SOD and vitamin C levels in PCa patients when compared with the BPH group.
This indicates that patients with BPH and prostate cancer have decreased antioxidant status and may benefit from micronutrient supplementation.
American Psychological Association (APA)
Duru, Romanda& Njoku, Obioma& Maduka, Ignatius. 2014. Oxidative Stress Indicators in Patients with Prostate Disorders in Enugu, South-East Nigeria. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-462618
Modern Language Association (MLA)
Duru, Romanda…[et al.]. Oxidative Stress Indicators in Patients with Prostate Disorders in Enugu, South-East Nigeria. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-462618
American Medical Association (AMA)
Duru, Romanda& Njoku, Obioma& Maduka, Ignatius. Oxidative Stress Indicators in Patients with Prostate Disorders in Enugu, South-East Nigeria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-462618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462618