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All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia : A Case Report and Literature Review
Joint Authors
Holmes, Dylan
Aboulafia, David M.
Vishnu, Prakash
Dorer, Russell K.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
All-trans retinoic acid (ATRA), a derivative of vitamin A, is an essential component in the treatment of acute promyelocytic leukemia (APL).
Though considered to be a relatively safe drug, use of ATRA can lead to several side effects such as retinoic acid syndrome and pseudotumor cerebri (PC).
PC is a rare disorder characterized by neurologic and ocular signs and symptoms of increased intracranial pressure, but with normal cerebrospinal fluid composition and normal brain imaging.
Most of the previous studies suggest that PC, as a complication of ATRA therapy, occurs predominantly in the pediatric age group.
Herein, we report a rare case of ATRA-induced PC in a 38-year-old woman undergoing induction treatment for APL.
Symptoms improved with discontinuation of ATRA and treatment with acetazolamide.
Concomitant administration of medications such as triazole antifungals which influence the cytochrome P-450 system can exacerbate this potential complication of ATRA.
In this paper, we also review the current literature, provide a descriptive analysis of clinical features, and discuss the principles of management of ATRA-induced PC.
American Psychological Association (APA)
Holmes, Dylan& Vishnu, Prakash& Dorer, Russell K.& Aboulafia, David M.. 2012. All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia : A Case Report and Literature Review. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-462621
Modern Language Association (MLA)
Holmes, Dylan…[et al.]. All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia : A Case Report and Literature Review. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-462621
American Medical Association (AMA)
Holmes, Dylan& Vishnu, Prakash& Dorer, Russell K.& Aboulafia, David M.. All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia : A Case Report and Literature Review. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-462621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462621