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Grape Seed Procyanidins in Pre- and Mild Hypertension : A Registry Study
Joint Authors
Ledda, Andrea
Feragalli, Beatrice
Belcaro, Gianni
Hu, Shu
Cesarone, Maria Rosa
Dugall, Mark
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The efficacy of a standardized grape seed procyanidins extract (GSPE, Enovita) to decrease blood pressure when associated with nondrug intervention (diet and lifestyle modifications) was investigated in a controlled registry study involving 119 healthy, pre- and mildly hypertensive subjects.
Two dosages of Enovita were evaluated (150 and 300 mg/die), using blood pressure and heart rate as the primary endpoints and complementing these observations with a laser Doppler flowmetry (LDF) investigation of the microcirculation state and an evaluation of the plasma oxidative status.
After four months of treatment, a statistically significant higher, and dose-dependent, improvement in all endpoints was observed in the treatment groups compared to that of the control, with blood pressure normalizing in 93% of the higher dosage (300 mg) treatment group.
Taken together, these observations suggest that GSPEs have beneficial cardiovascular effects that complement current intervention strategies in the hypertension area.
The effect on blood pressure adds to the beneficial effects of GSPEs on the cardiovascular disease (CVD) phenotype associated with the oxidation of membrane lipids (endothelial dysfunction, formation of oxidized LDL, and activation of phagocytic cells).
American Psychological Association (APA)
Belcaro, Gianni& Ledda, Andrea& Hu, Shu& Cesarone, Maria Rosa& Feragalli, Beatrice& Dugall, Mark. 2013. Grape Seed Procyanidins in Pre- and Mild Hypertension : A Registry Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-462624
Modern Language Association (MLA)
Belcaro, Gianni…[et al.]. Grape Seed Procyanidins in Pre- and Mild Hypertension : A Registry Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-462624
American Medical Association (AMA)
Belcaro, Gianni& Ledda, Andrea& Hu, Shu& Cesarone, Maria Rosa& Feragalli, Beatrice& Dugall, Mark. Grape Seed Procyanidins in Pre- and Mild Hypertension : A Registry Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-462624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462624