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A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing
Joint Authors
Spence, Andrew J.
Sell, Scott A.
Ericksen, Jeffery J.
Rodriguez, Isaac A.
McCool, Jennifer M.
Wolfe, Patricia S.
Bowlin, Gary L.
Garg, Koyal
Petrella, Rebecca L.
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aim.
The purpose of this study was to determine the in vitro response of cells critical to the wound healing process in culture media supplemented with a lyophilized preparation rich in growth factors (PRGF) and Manuka honey.
Materials and Methods.
This study utilized cell culture media supplemented with PRGF, as well as whole Manuka honey and the medical-grade Medihoney (MH), a Manuka honey product.
The response of human fibroblasts (hDF), macrophages, and endothelial cells (hPMEC) was evaluated, with respect to cell proliferation, chemotaxis, collagen matrix production, and angiogenic potential, when subjected to culture with media containing PRGF, MH, Manuka honey, and a combination of PRGF and MH.
Results.
All three cell types demonstrated increases in cellular activity in the presence of PRGF, with further increases in activity seen in the presence of PRGF+MH.
hDFs proved to be the most positively responsive cells, as they experienced enhanced proliferation, collagen matrix production, and migration into an in vitro wound healing model with the PRGF+MH-supplemented media.
Conclusion.
This preliminary in vitro study is the first to evaluate the combination of PRGF and Manuka honey, two products with the potential to increase regeneration individually, as a combined product to enhance dermal regeneration.
American Psychological Association (APA)
Sell, Scott A.& Wolfe, Patricia S.& Spence, Andrew J.& Rodriguez, Isaac A.& McCool, Jennifer M.& Petrella, Rebecca L.…[et al.]. 2012. A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-462661
Modern Language Association (MLA)
Sell, Scott A.…[et al.]. A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing. International Journal of Biomaterials No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-462661
American Medical Association (AMA)
Sell, Scott A.& Wolfe, Patricia S.& Spence, Andrew J.& Rodriguez, Isaac A.& McCool, Jennifer M.& Petrella, Rebecca L.…[et al.]. A Preliminary Study on the Potential of Manuka Honey and Platelet-Rich Plasma in Wound Healing. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-462661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462661