Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis
Joint Authors
Ciriaco, Miriam
Chimirri, Serafina
De Sarro, Giovambattista
Russo, Emilio
Patanè, Marinella
Gallelli, Luca
Grembiale, Rosa Daniela
Ursini, Francesco
Naty, Saverio
Source
Advances in Pharmacological Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Methotrexate (MTX) is a nonbiological disease-modifying antirheumatic drug that has shown both a good control of clinical disease and a good safety.
Usually drug-drug interactions (DDIs) represent the most limiting factor during the clinical management of any disease, in particular when several drugs are coadministered to treat the same disease.
In this paper, we report the interactions among MTX and the other drugs commonly used in the management of rheumatoid arthritis.
Using Medline, PubMed, Embase, Cochrane libraries, and Reference lists, we searched for the articles published until June 30, 2012, and we reported the most common DDIs between MTX and antirheumatic drugs.
In particular, clinically relevant DDIs have been described during the treatment with MTX and NSAIDs, for example, diclofenac, indomethacin, or COX-2 inhibitors, and between MTX and prednisone or immunosuppressant drugs (e.g., leflunomide and cyclosporine).
Finally, an increase in the risk of infections has been recorded during the combination treatment with MTX plus antitumor necrosis factor-α agents.
In conclusion, during the treatment with MTX, DDIs play an important role in both the development of ADRs and therapeutic failure.
American Psychological Association (APA)
Patanè, Marinella& Ciriaco, Miriam& Chimirri, Serafina& Ursini, Francesco& Naty, Saverio& Grembiale, Rosa Daniela…[et al.]. 2013. Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis. Advances in Pharmacological Sciences،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462669
Modern Language Association (MLA)
Patanè, Marinella…[et al.]. Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis. Advances in Pharmacological Sciences No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-462669
American Medical Association (AMA)
Patanè, Marinella& Ciriaco, Miriam& Chimirri, Serafina& Ursini, Francesco& Naty, Saverio& Grembiale, Rosa Daniela…[et al.]. Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis. Advances in Pharmacological Sciences. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462669