Microglia in Alzheimer's Disease : It's All About Context
Joint Authors
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neuroinflammation is now regarded as both an early event and prime mover in the pathobiology of Alzheimer disease (AD), a neurodegenerative disease that represents a growing public health threat.
As the resident innate immune cells within the central nervous system, microglia are centrally positioned as key orchestrators of brain inflammation.
It is now accepted that numerous forms of activated microglia exist.
Furthermore, while some types of reactive microglia are detrimental, others can actually be beneficial.
In the context of AD etiopathology, much debate surrounds whether these enigmatic cells play “good” or “bad” roles.
In this article, we distill a complex clinical and experimental literature focused on the contribution of microglia to AD pathology and progression.
A synthesis of the literature only seems possible when considering context– the conditions under which microglia encounter and mount immunological responses to AD pathology.
In order to carry out these diverse contextual responses, a number of key receptors and signaling pathways are variously activated.
It will be critically important for future studies to address molecular mediators that lead to beneficial microglial responses and therefore represent important therapeutic targets for AD.
American Psychological Association (APA)
Weitz, Tara M.& Town, Terrence. 2012. Microglia in Alzheimer's Disease : It's All About Context. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-462702
Modern Language Association (MLA)
Weitz, Tara M.& Town, Terrence. Microglia in Alzheimer's Disease : It's All About Context. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-462702
American Medical Association (AMA)
Weitz, Tara M.& Town, Terrence. Microglia in Alzheimer's Disease : It's All About Context. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-462702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462702