LDL-Apheresis : Technical and Clinical Aspects
Joint Authors
Schiel, Ralf
Bambauer, Rolf
Latza, Reinhard
Lehmann, Boris
Bambauer, Carolin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The prognosis of patients suffering from severe hyperlipidemia, sometimes combined with elevated lipoprotein (a) levels, and coronary heart disease refractory to diet and lipid-lowering drugs is poor.
For such patients, regular treatment with low-density lipoprotein (LDL) apheresis is the therapeutic option.
Today, there are five different LDL-apheresis systems available: cascade filtration or lipid filtration, immunoadsorption, heparin-induced LDL precipitation, dextran sulfate LDL adsorption, and the LDL hemoperfusion.
There is a strong correlation between hyperlipidemia and atherosclerosis.
Besides the elimination of other risk factors, in severe hyperlipidemia therapeutic strategies should focus on a drastic reduction of serum lipoproteins.
Despite maximum conventional therapy with a combination of different kinds of lipid-lowering drugs, sometimes the goal of therapy cannot be reached.
Hence, in such patients, treatment with LDL-apheresis is indicated.
Technical and clinical aspects of these five different LDL-apheresis methods are shown here.
There were no significant differences with respect to or concerning all cholesterols, or triglycerides observed.
With respect to elevated lipoprotein (a) levels, however, the immunoadsorption method seems to be most effective.
The different published data clearly demonstrate that treatment with LDL-apheresis in patients suffering from severe hyperlipidemia refractory to maximum conservative therapy is effective and safe in long-term application.
American Psychological Association (APA)
Bambauer, Rolf& Bambauer, Carolin& Lehmann, Boris& Latza, Reinhard& Schiel, Ralf. 2012. LDL-Apheresis : Technical and Clinical Aspects. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-462716
Modern Language Association (MLA)
Bambauer, Rolf…[et al.]. LDL-Apheresis : Technical and Clinical Aspects. The Scientific World Journal No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-462716
American Medical Association (AMA)
Bambauer, Rolf& Bambauer, Carolin& Lehmann, Boris& Latza, Reinhard& Schiel, Ralf. LDL-Apheresis : Technical and Clinical Aspects. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-462716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462716