The Impact of Antiviral Therapy and the Influence of Metabolic Cofactors on the Outcome of Chronic HCV Infection
Joint Authors
Costantino, Andrea
Almasio, Piero Luigi
Bruno, Savino
Mazza, Marta
Persico, Marcello
Source
International Journal of Hepatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Natural history of HCV related chronic hepatitis is influenced and modified by many factors: virus features, coinfections and host characteristics.
In particular, a peculiar genetic background of the host by conditioning the occurrence of intracellular metabolic derangements (i.e., insulin resistance) might contribute to accelerate the rate of progression to cirrhosis and eventually the occurrence of hepatocellular carcinoma (HCC) and death.
Likely, direct interplays between virus genotype and host genetic background might be hypothesized at this level.
Morbidity and mortality in cirrhosis is primarily associated with complications of liver cirrhosis (ascites, hepatic encephalopathy, jaundice, and gastroesophageal bleeding) and HCC occurrence.
Therefore the main goal of therapy is to clear viral infection and decrease liver necro-inflammation that directly relates to development of cirrhosis and HCC.
Among patients treated with Interferon-based therapy, those with sustained viral response showed a significant reduction of progression to cirrhosis and development of HCC.
However, a residual risk of hepatocellular carcinoma still remains indicating the need for careful follow-up using ultrasonography every six months in cirrhotic patients, even in those showing persistently normal ALT and undetectable HCV RNA levels after antiviral therapy.
American Psychological Association (APA)
Persico, Marcello& Bruno, Savino& Costantino, Andrea& Mazza, Marta& Almasio, Piero Luigi. 2011. The Impact of Antiviral Therapy and the Influence of Metabolic Cofactors on the Outcome of Chronic HCV Infection. International Journal of Hepatology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462720
Modern Language Association (MLA)
Persico, Marcello…[et al.]. The Impact of Antiviral Therapy and the Influence of Metabolic Cofactors on the Outcome of Chronic HCV Infection. International Journal of Hepatology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-462720
American Medical Association (AMA)
Persico, Marcello& Bruno, Savino& Costantino, Andrea& Mazza, Marta& Almasio, Piero Luigi. The Impact of Antiviral Therapy and the Influence of Metabolic Cofactors on the Outcome of Chronic HCV Infection. International Journal of Hepatology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462720