![](/images/graphics-bg.png)
Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres
Joint Authors
Cassoni, Paola
Caldera, Valentina
Schiffer, Davide
Mellai, Marta
Annovazzi, Laura
Piazzi, Angela
Lanotte, Michele
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Formation of neurospheres (NS) in cultures of glioblastomas (GBMs), with self-renewal, clonogenic capacities, and tumorigenicity following transplantation into immunodeficient mice, may denounce the existence of brain tumor stem cells (BTSCs) in vivo.
In sixteen cell lines from resected primary glioblastomas, NS showed the same genetic alterations as primary tumors and the expression of stemness antigens.
Adherent cells (AC), after adding 10% of fetal bovine serum (FBS) to the culture, were genetically different from NS and prevailingly expressed differentiation antigens.
NS developed from a highly malignant tumor phenotype with proliferation, circumscribed necrosis, and high vessel density.
Beside originating from transformed neural stem cells (NSCs), BTSCs may be contained within or correspond to dedifferentiated cells after mutation accumulation, which reacquire the expression of stemness antigens.
American Psychological Association (APA)
Caldera, Valentina& Mellai, Marta& Annovazzi, Laura& Piazzi, Angela& Lanotte, Michele& Cassoni, Paola…[et al.]. 2011. Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres. Journal of Oncology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-462774
Modern Language Association (MLA)
Caldera, Valentina…[et al.]. Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres. Journal of Oncology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-462774
American Medical Association (AMA)
Caldera, Valentina& Mellai, Marta& Annovazzi, Laura& Piazzi, Angela& Lanotte, Michele& Cassoni, Paola…[et al.]. Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-462774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462774