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Surgery and Actinomycin Improve Survival in Malignant Rhabdoid Tumor
Joint Authors
Cheng, Edward Y.
Horazdovsky, Ryan
Manivel, J. Carlos
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Malignant rhabdoid tumor (MRT) is an uncommon tumor that rarely occurs outside of renal and central nervous system (CNS) sites.
Data from the literature were compiled to determine prognostic factors, including both demographic and treatment variables of malignant rhabdoid tumor, focusing on those tumors arising in extra-renal, extra-CNS (ER/EC MRT) sites.
Patients and Methods.
A systematic review and meta-analysis was performed by extracting demographic, treatment, and survival follow up on 167 cases of primary ER/EC MRT identified in the literature.
Results.
No survival differences were observed between those treated with or without radiation, or with or without chemotherapy.
A Cox regression of overall survival revealed several independent prognostic factors.
Surgical excision had a 74% (P = 0.0003) improvement in survival.
Actinomycin had a 73% (P = 0.093) improvement in survival.
Older age was associated with improved survival.
The four-year survival, by Kaplan-Meier estimates, comparing patients less than two years old versus older than two at diagnosis was 11% versus 35%, respectively (P = 0.0001, Log-Rank).
Conclusion.
ER/EC MRT is a rare, soft-tissue tumor with a poor prognosis most commonly occurring in children.
Surgical resection, treatment with actinomycin, and older age at diagnosis are all associated with improved survival.
American Psychological Association (APA)
Horazdovsky, Ryan& Manivel, J. Carlos& Cheng, Edward Y.. 2013. Surgery and Actinomycin Improve Survival in Malignant Rhabdoid Tumor. Sarcoma،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462799
Modern Language Association (MLA)
Horazdovsky, Ryan…[et al.]. Surgery and Actinomycin Improve Survival in Malignant Rhabdoid Tumor. Sarcoma No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-462799
American Medical Association (AMA)
Horazdovsky, Ryan& Manivel, J. Carlos& Cheng, Edward Y.. Surgery and Actinomycin Improve Survival in Malignant Rhabdoid Tumor. Sarcoma. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462799