Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis
Joint Authors
Gresle, Melissa M.
Shaw, Gerry
Butzkueven, Helmut
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Biomarkers of axonal degeneration have the potential to improve our capacity to predict and monitor neurological outcome in multiple sclerosis (MS) patients.
Neurofilament proteins, one of the major proteins expressed within neurons and axons, have been detected in cerebrospinal fluid and blood samples from MS patients and are now being actively investigated for their utility as prognostic indicators of disease progression in MS.
In this paper, we summarize the current literature on neurofilament structure, assembly, and degeneration and discuss their potential utility as biomarkers for monitoring neurological decline in MS.
We also discuss the need to further develop sensitive methods for assaying neurofilaments in blood to improve clinical applicability.
American Psychological Association (APA)
Gresle, Melissa M.& Butzkueven, Helmut& Shaw, Gerry. 2011. Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462808
Modern Language Association (MLA)
Gresle, Melissa M.…[et al.]. Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-462808
American Medical Association (AMA)
Gresle, Melissa M.& Butzkueven, Helmut& Shaw, Gerry. Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462808