Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice
Joint Authors
Shirasawa, Takuji
Shimizu, Takahiko
Ogawara, Midori
Baba, Tomonori
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Insulin/insulin-like growth factor type 1 signaling regulates lifespan and resistance to oxidative stress in worms, flies, and mammals.
In a previous study, we revealed that insulin receptor (IR) mutant mice, which carry a homologous mutation found in the long-lived daf-2 mutant of Caenorhabditis elegans, showed enhanced resistance to oxidative stress cooperatively modulated by sex hormones and dietary signals (Baba et al., (2005)).
We herein investigated the lifespan of IR mutant mice to evaluate the biological significance of insulin signaling in mice.
Under normoxia, mutant male mice had a lifespan comparable to that of wild-type male mice.
IR mutant female mice also showed a lifespan similar to that of wild-type female mice, in spite of the fact that the IR mutant female mice acquired more resistance to oxidative stress than IR mutant male mice.
On the other hand, IR mutant male and female mice both showed insulin resistance with hyperinsulinemia, but they did not develop hyperglycemia throughout their entire lifespan.
These data indicate that the IR mutation does not impact the lifespan in mice, thus suggesting that insulin signaling might have a limited effect on the lifespan of mice.
American Psychological Association (APA)
Shimizu, Takahiko& Baba, Tomonori& Ogawara, Midori& Shirasawa, Takuji. 2011. Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462821
Modern Language Association (MLA)
Shimizu, Takahiko…[et al.]. Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice. Journal of Aging Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462821
American Medical Association (AMA)
Shimizu, Takahiko& Baba, Tomonori& Ogawara, Midori& Shirasawa, Takuji. Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462821