Uniform Suspension of the Clustered Triamcinolone Acetonide Particle
Joint Authors
Sugimoto, Masahiko
Kondo, Mineo
Horiguchi, Masayuki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
MaQaid (MaQ) is a new triamcinolone acetonide commercialised in Japan to visualize the vitreous.
Because MaQ is preservative-free, it has a lower risk of ocular toxicities.
However, since MaQ is only available as a powder, it needs suspenssion.
Suspension does not always result uniformally, which causes poor visibility.
This study reports a new MaQ suspension for better visibility.
Methods.
After medium addition to a MaQ vial, various methods were used.
These included the use of (1) vortex mixer, (2) two syringes and a three-way stopcock, and (3) ultrasonic washer.
We calculated suspended MaQ concentration (n=5).
To evaluate the reproducibility, we estimated the coefficient of variance (CV, n=3).
We used this MaQ for pig eyes, and vitreous visualization was simulated.
Subsequently, we used this MaQ suspension for humans.
Results.
MaQ suspensions were sucessfull, and the concentrations of single particles increased significantly (P<0.01).
The CV was 36.1% for the routine method and 9.03% ffor the new method.
Administration of a suspended MaQ made it possible to clearly visualize the vitreous in both pig and human eyes.
Conclusions.
We devised new techniques for uniformal MaQ suspension.
These new methods can compensate for the MaQ disadvantages and ensure a safety surgery.
American Psychological Association (APA)
Sugimoto, Masahiko& Kondo, Mineo& Horiguchi, Masayuki. 2013. Uniform Suspension of the Clustered Triamcinolone Acetonide Particle. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462823
Modern Language Association (MLA)
Sugimoto, Masahiko…[et al.]. Uniform Suspension of the Clustered Triamcinolone Acetonide Particle. Journal of Ophthalmology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-462823
American Medical Association (AMA)
Sugimoto, Masahiko& Kondo, Mineo& Horiguchi, Masayuki. Uniform Suspension of the Clustered Triamcinolone Acetonide Particle. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462823