Cattle Bile Aggravates Diclofenac Sodium-Induced Small Intestinal Injury in Mice
Joint Authors
Ishikawa, Hironori
Watanabe, Shiro
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cattle bile (CB) has long been used in Japan as an ingredient of digestive medicines.
Bile acids are major chemical constituents of CB, and CB ingestion is assumed to affect small intestinal injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs).
Mice were fed a diet supplemented with or without CB for 7 days and treated with diclofenac sodium (DIF) to induce small intestinal injury.
Lesion formation was enhanced, and PGE2 content and COX expression levels were elevated in the small intestine of DIF-treated mice fed the CB diet compared with those fed the control diet.
The administration of a reconstituted mixture of bile acids found in CB enhanced lesion formation in DIF-treated mice.
CB administration elevated the contents of CB-derived bile acids in the small intestine, some of which exhibited a high cytotoxicity to cultured intestinal epithelial cells.
These results suggest that the elevated levels of CB-derived cytotoxic bile acids in the small intestine contribute to the aggravation of DIF-induced small intestinal injury.
The use of CB may be limited during the therapy of inflammatory diseases with NSAIDs.
American Psychological Association (APA)
Ishikawa, Hironori& Watanabe, Shiro. 2011. Cattle Bile Aggravates Diclofenac Sodium-Induced Small Intestinal Injury in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462846
Modern Language Association (MLA)
Ishikawa, Hironori& Watanabe, Shiro. Cattle Bile Aggravates Diclofenac Sodium-Induced Small Intestinal Injury in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-462846
American Medical Association (AMA)
Ishikawa, Hironori& Watanabe, Shiro. Cattle Bile Aggravates Diclofenac Sodium-Induced Small Intestinal Injury in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-462846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462846