Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique
Joint Authors
Deshmukh, P. K.
Kapure, V. J.
Pande, Vishal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT).
The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions.
In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders.
Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR) analysis, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication.
As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.
American Psychological Association (APA)
Kapure, V. J.& Pande, Vishal& Deshmukh, P. K.. 2013. Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-462851
Modern Language Association (MLA)
Kapure, V. J.…[et al.]. Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique. Journal of Pharmaceutics No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-462851
American Medical Association (AMA)
Kapure, V. J.& Pande, Vishal& Deshmukh, P. K.. Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-462851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462851