Molecular Classification of Hepatocellular Adenomas
Joint Authors
Nault, Jean Charles
Zucman Rossi, Jessica
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hepatocellular adenomas (HCAs) are benign tumors developed in normal liver most frequently in women before menopause.
HCAs lead to diagnostic pitfalls and several difficulties to assess the risk of malignant transformation in these young patients.
Recent advances in basic knowledge have revealed a molecular classification related to risk factors, pathological features, and risk of transformation in hepatocellular carcinoma.
Three major molecular pathways have been identified altered in specific HCA subgroups that are defined by either (1) inactivation of hepatocyte nuclear factor 1A (HNF1A) transcription factor, (2) activation of the WNT/β-catenin by CTNNB1 mutations, or (3) activation of the IL6/STAT3 pathway by somatic mutation of IL6ST, GNAS, or STAT3.
Here, we will review the different molecular classes of HCA.
American Psychological Association (APA)
Nault, Jean Charles& Zucman Rossi, Jessica. 2013. Molecular Classification of Hepatocellular Adenomas. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462858
Modern Language Association (MLA)
Nault, Jean Charles& Zucman Rossi, Jessica. Molecular Classification of Hepatocellular Adenomas. International Journal of Hepatology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462858
American Medical Association (AMA)
Nault, Jean Charles& Zucman Rossi, Jessica. Molecular Classification of Hepatocellular Adenomas. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462858