Molecular Classification of Hepatocellular Adenomas

Joint Authors

Nault, Jean Charles
Zucman Rossi, Jessica

Source

International Journal of Hepatology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-01-15

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Hepatocellular adenomas (HCAs) are benign tumors developed in normal liver most frequently in women before menopause.

HCAs lead to diagnostic pitfalls and several difficulties to assess the risk of malignant transformation in these young patients.

Recent advances in basic knowledge have revealed a molecular classification related to risk factors, pathological features, and risk of transformation in hepatocellular carcinoma.

Three major molecular pathways have been identified altered in specific HCA subgroups that are defined by either (1) inactivation of hepatocyte nuclear factor 1A (HNF1A) transcription factor, (2) activation of the WNT/β-catenin by CTNNB1 mutations, or (3) activation of the IL6/STAT3 pathway by somatic mutation of IL6ST, GNAS, or STAT3.

Here, we will review the different molecular classes of HCA.

American Psychological Association (APA)

Nault, Jean Charles& Zucman Rossi, Jessica. 2013. Molecular Classification of Hepatocellular Adenomas. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462858

Modern Language Association (MLA)

Nault, Jean Charles& Zucman Rossi, Jessica. Molecular Classification of Hepatocellular Adenomas. International Journal of Hepatology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462858

American Medical Association (AMA)

Nault, Jean Charles& Zucman Rossi, Jessica. Molecular Classification of Hepatocellular Adenomas. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462858

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-462858