Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties
Joint Authors
Bennikallu Hire Mathada, Mruthyunjayaswamy
Karekal, Mahendra Raj
Biradar, Vivekanand
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
A new Schiff base of 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide and 3-formyl-2-hydroxy-1H-quinoline (HL), and its Cu(II), Co(II), Ni(II), Zn(II), Cd(II), and Hg(II) complexes have been synthesized and characterized in the light of microanalytical, IR, H1 NMR, UV-Vis, FAB-mass, ESR, XRD, and TGA spectral studies.
The magnetic susceptibility measurements and low conductivity data provide evidence for monomeric and neutral nature of the complexes.
On the basis of spectral studies and analytical data, it is evident that the Schiff base acts as tridentate ligand.
The Cu(II), Co(II), and Ni(II) complexes were octahedral, whereas Zn(II), Cd(II), and Hg(II) complexes were tetrahedral in nature.
The redox behavior of the Cu(II) complex was investigated by electrochemical method using cyclic voltammetry.
In order to evaluate the effect of metal ions upon chelation, both the ligand and its metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method.
The DNA cleavage experiment performed using agarose gel electrophoresis method showed the cleavage of DNA by all the metal complexes.
The free radical scavenging activity of newly synthesized compounds has been determined at a different concentration range by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH).
American Psychological Association (APA)
Karekal, Mahendra Raj& Biradar, Vivekanand& Bennikallu Hire Mathada, Mruthyunjayaswamy. 2013. Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-462861
Modern Language Association (MLA)
Karekal, Mahendra Raj…[et al.]. Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-462861
American Medical Association (AMA)
Karekal, Mahendra Raj& Biradar, Vivekanand& Bennikallu Hire Mathada, Mruthyunjayaswamy. Synthesis, Characterization, Antimicrobial, DNA Cleavage, and Antioxidant Studies of Some Metal Complexes Derived from Schiff Base Containing Indole and Quinoline Moieties. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-462861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462861