Mechanisms of Remodeling in Asthmatic Airways
Joint Authors
Shifren, Adrian
Witt, Chad
Christie, Chandrika
Castro, Mario
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Asthma is a chronic inflammatory airway disorder characterized by airway hyperresponsiveness and reversible airflow obstruction.
Subgroups of asthma patients develop airflow obstruction that is irreversible or only partially reversible and experience an accelerated rate of lung function decline.
The structural changes in the airways of these patients are referred to as airway remodeling.
All elements of the airway wall are involved, and remodeled airway wall thickness is substantially increased compared to normal control airways.
Airway remodeling is thought to contribute to the subphenotypes of irreversible airflow obstruction and airway hyperresponsiveness, and it has been associated with increased disease severity.
Reversal of remodeling is therefore of paramount therapeutic importance, and mechanisms responsible for airway remodeling are feasible therapeutic targets for asthma treatment.
This paper will focus on our current understanding of the mechanisms of airway remodeling in asthma and potential targets for future intervention.
American Psychological Association (APA)
Shifren, Adrian& Witt, Chad& Christie, Chandrika& Castro, Mario. 2012. Mechanisms of Remodeling in Asthmatic Airways. Journal of Allergy،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-462875
Modern Language Association (MLA)
Shifren, Adrian…[et al.]. Mechanisms of Remodeling in Asthmatic Airways. Journal of Allergy No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-462875
American Medical Association (AMA)
Shifren, Adrian& Witt, Chad& Christie, Chandrika& Castro, Mario. Mechanisms of Remodeling in Asthmatic Airways. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-462875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462875