Genetic Immunization with CDR3-Based Fusion Vaccine Confers Protection and Long-Term Tumor-Free Survival in a Mouse Model of Lymphoma
Joint Authors
Rinaldi, Monica
Signori, Emanuela
Fioretti, Daniela
Zonfrillo, Manuela
Iurescia, Sandra
Fazio, Vito Michele
Pierimarchi, Pasquale
Tonon, Giancarlo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Therapeutic vaccination against idiotype is a promising strategy for immunotherapy of B-cell malignancies.
We have previously shown that CDR3-based DNA immunization can induce immune response against lymphoma and explored this strategy to provide protection in a murine B-cell lymphoma model.
Here we performed vaccination employing as immunogen a naked DNA fusion product.
The DNA vaccine was generated following fusion of a sequence derived from tetanus toxin fragment C to the VHCDR3109−116 epitope.
Induction of tumor-specific immunity as well as ability to inhibit growth of the aggressive 38C13 lymphoma and to prolong survival of vaccinated mice has been tested.
We determined that DNA fusion vaccine induced immune response, elicited a strong protective antitumor immunity, and ensured almost complete long-term tumor-free survival of vaccinated mice.
Our results show that CDR3-based DNA fusion vaccines hold promise for vaccination against lymphoma.
American Psychological Association (APA)
Iurescia, Sandra& Fioretti, Daniela& Pierimarchi, Pasquale& Signori, Emanuela& Zonfrillo, Manuela& Tonon, Giancarlo…[et al.]. 2010. Genetic Immunization with CDR3-Based Fusion Vaccine Confers Protection and Long-Term Tumor-Free Survival in a Mouse Model of Lymphoma. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-462878
Modern Language Association (MLA)
Iurescia, Sandra…[et al.]. Genetic Immunization with CDR3-Based Fusion Vaccine Confers Protection and Long-Term Tumor-Free Survival in a Mouse Model of Lymphoma. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-462878
American Medical Association (AMA)
Iurescia, Sandra& Fioretti, Daniela& Pierimarchi, Pasquale& Signori, Emanuela& Zonfrillo, Manuela& Tonon, Giancarlo…[et al.]. Genetic Immunization with CDR3-Based Fusion Vaccine Confers Protection and Long-Term Tumor-Free Survival in a Mouse Model of Lymphoma. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-462878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462878
