Association between Postmenopausal Osteoporosis and Experimental Periodontitis
Joint Authors
Huang, Yongling
Xiao, Yin
Guo, Jianbin
Ma, Souzhi
Luo, Kai
Yan, Fuhua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To investigate the correlation between postmenopausal osteoporosis (PMO) and the pathogenesis of periodontitis, ovariectomized rats were generated and the experimental periodontitis was induced using a silk ligature.
The inflammatory factors and bone metabolic markers were measured in the serum and periodontal tissues of ovariectomized rats using an automatic chemistry analyzer, enzyme-linked immunosorbent assays, and immunohistochemistry.
The bone mineral density of whole body, pelvis, and spine was analyzed using dual-energy X-ray absorptiometry and image analysis.
All data were analyzed using SPSS 13.0 statistical software.
It was found that ovariectomy could upregulate the expression of interleukin- (IL-)6, the receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG) and downregulate IL-10 expression in periodontal tissues, which resulted in progressive alveolar bone loss in experimental periodontitis.
This study indicates that changes of cytokines and bone turnover markers in the periodontal tissues of ovariectomized rats contribute to the damage of periodontal tissues.
American Psychological Association (APA)
Luo, Kai& Ma, Souzhi& Guo, Jianbin& Huang, Yongling& Yan, Fuhua& Xiao, Yin. 2014. Association between Postmenopausal Osteoporosis and Experimental Periodontitis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-462883
Modern Language Association (MLA)
Luo, Kai…[et al.]. Association between Postmenopausal Osteoporosis and Experimental Periodontitis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-462883
American Medical Association (AMA)
Luo, Kai& Ma, Souzhi& Guo, Jianbin& Huang, Yongling& Yan, Fuhua& Xiao, Yin. Association between Postmenopausal Osteoporosis and Experimental Periodontitis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-462883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462883