Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease : A Randomized Controlled Trial
Joint Authors
Wen, Xiaofeng
Wang, Yongyan
Zhou, Hongying
Li, Xiuhui
Lu, Cheng
Ding, Xiaorong
Liu, Yan
Liang, Lanchun
Yang, Huasheng
Shi, Qingsheng
Lu, Ai-ping
Zhu, Qingxiong
Zhang, Zhiying
Tian, Yimei
Yang, Tong
Zhang, Chi
Jiang, Zhongsheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Herb-derived compound andrographolide sulfonate (called Xiyanping injection) recommended control measure for severe hand, foot, and mouth disease (HFMD) by the Ministry of Health (China) during the 2010 epidemic.
However, there is a lack of good quality evidence directly comparing the efficacy of Andrographolide Sulfonate combination therapy with conventional therapy.
Methods.
230 patients were randomly assigned to 7–10 days of Andrographolide Sulfonate 5–10 mg/Kg/day and conventional therapy, or conventional therapy alone.
Results.
The major complications occurred less often after Andrographolide Sulfonate (2.6% versus 12.1%; risk difference [RD], 0.94; 95% CI, 0.28–1.61; P=0.006).
Median fever clearance times were 96 hours (CI, 80 to 126) for conventional therapy recipients and 48 hours (CI, 36 to 54) for Andrographolide Sulfonate combination-treated patients (χ2=16.57, P<0.001).
The two groups did not differ in terms of HFMD-cause mortality (P=1.00) and duration of hospitalization (P=0.70).
There was one death in conventional therapy group.
No important adverse event was found in Andrographolide Sulfonate combination therapy group.
Conclusions.
The addition of Andrographolide Sulfonate to conventional therapy reduced the occurrence of major complications, fever clearance time, and the healing time of typical skin or oral mucosa lesions in children with severe HFMD.
American Psychological Association (APA)
Li, Xiuhui& Zhang, Chi& Shi, Qingsheng& Yang, Tong& Zhu, Qingxiong& Tian, Yimei…[et al.]. 2013. Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease : A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462895
Modern Language Association (MLA)
Li, Xiuhui…[et al.]. Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease : A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-462895
American Medical Association (AMA)
Li, Xiuhui& Zhang, Chi& Shi, Qingsheng& Yang, Tong& Zhu, Qingxiong& Tian, Yimei…[et al.]. Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease : A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-462895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462895