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Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH
Joint Authors
Ghimire Gautam, Sunita
Nishigaki, Koichi
Biyani, Madhu
Komatsu, Masayuki
Source
International Journal of Peptides
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Enzymes are regulated by their activation and inhibition.
Enzyme activators can often be effective tools for scientific and medical purposes, although they are more difficult to obtain than inhibitors.
Here, using the paired peptide method, we report on protease-cathepsin-E-activating peptides that are obtained at neutral pH.
These selected peptides also underwent molecular evolution, after which their cathepsin E activation capability improved.
Thus, the activators we obtained could enhance cathepsin-E-induced cancer cell apoptosis, which indicated their potential as cancer drug precursors.
American Psychological Association (APA)
Komatsu, Masayuki& Biyani, Madhu& Ghimire Gautam, Sunita& Nishigaki, Koichi. 2012. Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH. International Journal of Peptides،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462913
Modern Language Association (MLA)
Komatsu, Masayuki…[et al.]. Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH. International Journal of Peptides No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-462913
American Medical Association (AMA)
Komatsu, Masayuki& Biyani, Madhu& Ghimire Gautam, Sunita& Nishigaki, Koichi. Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH. International Journal of Peptides. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-462913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462913