Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia in the elderly.
Patients with AD suffer a gradual deterioration of memory and other cognitive functions, which eventually leads to a complete incapacity and death.
A complicated array of molecular events has been implicated in the pathogenesis of AD.
The major pathological characteristics of AD brains are the presence of senile plaques, neurofibrillary tangles, and neuronal loss.
Growing evidence has demonstrated that oxidative stress is an important factor contributing to the initiation and progression of AD.
However, the mechanisms that lead to the disruption of redox balance and the sources of free radicals remain elusive.
The excessive reactive oxygen species may be generated from mechanisms such as mitochondria dysfunction and/or aberrant accumulation of transition metals, while the abnormal accumulation of Abeta and tau proteins appears to promote the redox imbalance.
The resulted oxidative stress has been implicated in Abeta- or tau-induced neurotoxicity.
In addition, evidence has suggested that oxidative stress may augment the production and aggregation of Abeta and facilitate the phosphorylation and polymerization of tau, thus forming a vicious cycle that promotes the initiation and progression of AD.
American Psychological Association (APA)
Zhao, Yan& Zhao, Baolu. 2013. Oxidative Stress and the Pathogenesis of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462918
Modern Language Association (MLA)
Zhao, Yan& Zhao, Baolu. Oxidative Stress and the Pathogenesis of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-462918
American Medical Association (AMA)
Zhao, Yan& Zhao, Baolu. Oxidative Stress and the Pathogenesis of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-462918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462918