Synonymous Codon Usage Analysis of Thirty Two Mycobacteriophage Genomes
Joint Authors
Mahalingam, Vasantha
Kumar, Vanaja
Hassan, Sameer
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Synonymous codon usage of protein coding genes of thirty two completely sequenced mycobacteriophage genomes was studied using multivariate statistical analysis.
One of the major factors influencing codon usage is identified to be compositional bias.
Codons ending with either C or G are preferred in highly expressed genes among which C ending codons are highly preferred over G ending codons.
A strong negative correlation between effective number of codons (Nc) and GC3s content was also observed, showing that the codon usage was effected by gene nucleotide composition.
Translational selection is also identified to play a role in shaping the codon usage operative at the level of translational accuracy.
High level of heterogeneity is seen among and between the genomes.
Length of genes is also identified to influence the codon usage in 11 out of 32 phage genomes.
Mycobacteriophage Cooper is identified to be the highly biased genome with better translation efficiency comparing well with the host specific tRNA genes.
American Psychological Association (APA)
Hassan, Sameer& Mahalingam, Vasantha& Kumar, Vanaja. 2010. Synonymous Codon Usage Analysis of Thirty Two Mycobacteriophage Genomes. Advances in Bioinformatics،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-462948
Modern Language Association (MLA)
Hassan, Sameer…[et al.]. Synonymous Codon Usage Analysis of Thirty Two Mycobacteriophage Genomes. Advances in Bioinformatics No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-462948
American Medical Association (AMA)
Hassan, Sameer& Mahalingam, Vasantha& Kumar, Vanaja. Synonymous Codon Usage Analysis of Thirty Two Mycobacteriophage Genomes. Advances in Bioinformatics. 2010. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-462948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462948