In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives
Joint Authors
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Activator protein-1 (AP1) is a transcription factor that consists of the Jun and Fos family proteins.
It regulates gene expression in response to a variety of stimuli and controls cellular processes including proliferation, transformation, inflammation, and innate immune responses.
AP1 binds specifically to 12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element 5′-TGAG/CTCA-3′ (AP1 site).
It has been found constitutively active in breast, ovarian, cervical, and lung cancers.
Numerous studies have shown that inhibition of AP1 could be a promising strategy for cancer therapeutic applications.
The present in silico study provides insights into the inhibition of Jun-Fos-DNA complex formation by curcumin derivatives.
These derivatives interact with the amino acid residues like Arg155 and Arg158 which play a key role in binding of Jun-Fos complex to DNA (AP1 site).
Ala151, Ala275, Leu283, and Ile286 were the residues present at binding site which could contribute to hydrophobic contacts with inhibitor molecules.
Curcumin sulphate was predicted to be the most potent inhibitor amongst all the natural curcumin derivatives docked.
American Psychological Association (APA)
Kumar, Anil& Bora, Utpal. 2012. In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives. International Journal of Medicinal Chemistry،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462953
Modern Language Association (MLA)
Kumar, Anil& Bora, Utpal. In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives. International Journal of Medicinal Chemistry No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-462953
American Medical Association (AMA)
Kumar, Anil& Bora, Utpal. In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives. International Journal of Medicinal Chemistry. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462953