The Role of the Dysfunctional Akt-Related Pathway in Cancer : Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Akt serine/threonine kinases, or PKB, are key players in the regulation of a wide variety of cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of DNA damage responses and genome stability, metabolism, migration, and angiogenesis.
The Akt-related pathway responds to the stimulation mediated by growth factors, cytokines, hormones, and several nutrients.
Akt is present in three isoforms: Akt1, Akt2, and Akt3, which may be alternatively named PKBα, PKBβ, and PKBγ, respectively.
The Akt isoforms are encoded on three diverse chromosomes and their biological functions are predominantly distinct.
Deregulations in the Akt-related pathway were observed in many human maladies, including cancer, cardiopathies, neurological diseases, and type-2 diabetes.
This review discusses the significance of the abnormal activities of the Akt axis in promoting and sustaining malignancies, along with the development of tumor cell populations that exhibit enhanced resistance to chemo- and/or radiotherapy.
This occurrence may be responsible for the relapse of the disease, which is unfortunately very often related to fatal consequences in patients.
American Psychological Association (APA)
Romano, Gaetano. 2013. The Role of the Dysfunctional Akt-Related Pathway in Cancer : Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development. Scientifica،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462980
Modern Language Association (MLA)
Romano, Gaetano. The Role of the Dysfunctional Akt-Related Pathway in Cancer : Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development. Scientifica No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-462980
American Medical Association (AMA)
Romano, Gaetano. The Role of the Dysfunctional Akt-Related Pathway in Cancer : Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-462980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462980