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Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis
Joint Authors
Atkin, Julie D.
Walker, Adam K.
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by the progressive loss of motor neurons, leading to paralysis and death within several years of onset.
Although protein misfolding is a key feature of ALS, the upstream triggers of disease remain elusive.
Recently, endoplasmic reticulum (ER) stress was identified as an early and central feature in ALS disease models as well as in human patient tissues, indicating that ER stress could be an important process in disease pathogenesis.
One important chaperone induced by ER stress is protein disulphide isomerase (PDI), which is both upregulated and posttranslationally inhibited by S-nitrosylation in ALS.
In this paper, we present evidence from studies of genetics, model organisms, and patient tissues which indicate an active role for PDI and ER stress in ALS disease processes.
American Psychological Association (APA)
Walker, Adam K.& Atkin, Julie D.. 2011. Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis. Neurology Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462993
Modern Language Association (MLA)
Walker, Adam K.& Atkin, Julie D.. Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis. Neurology Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-462993
American Medical Association (AMA)
Walker, Adam K.& Atkin, Julie D.. Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-462993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462993